Pergamon was the home city of Hiera, the wife of Telephus, son of Hercules, who in the Trojan war commanded the Mysian (Izmir region) women on horseback and thought on the side of Trojans. Late traditions described her as excelling in beauty Helena herself. She fell by the hand of Nireus. The ancient site of the city of Ephesus was dedicated to the goddess Artemis. Her enormous temple, rebuilt several times, dates in its latest form from the third century B.C. and was considered one of the Seven Wonders of the ancient world. Between Kusadasi's southern shores and Pamukkale lies the valley of the Menderes River (the Meander), where several ancient civilizations built major settlements, including Priene, Milet, Didyma (Didim), Aphrodisias and Hierapolis (Pamukkale). The Temple of Apollo at Didyma was one of the most sacred places of antiquity.