According to mythology, the Minoans founded the city of Minoa on the island of Amorgos during the Minoan period. It is believed that King Minos ruled the island. He was the son of Zeus and Europa, reigned over Crete and the islands of the Aegean Sea three generations before the Trojan War. He was the author of the Cretan constitution and the founder of its naval supremacy. In revenge for the death of his son Androgeus during a riot, every nine years, Minos made King Aegeus pick seven young boys and seven young girls to be sent to Daedalus's creation, the labyrinth, to be eaten by the Minotaur. After his death, Minos became a judge of the dead in the underworld.
However, another myth states that Minoa was a colony of Samos while Arkesini was a colony of Naxos and Aegialis was a colony of the Milecians. Those three cities formed the Tripolis of Amorgos.
In antiquity, Amorgos was famous for the Hydromanteion of Apollo that was located on the present location of the Church of Agios Georgios Valsamitis.
A legend says that the name of the island derives from amorgos, a rare healing herb growing in the mountains of Amorgos.